Novel fluoroimmunoassay for ovarian cancer biomarker CA-125

Sok, Davin and Clarizia, LJ and Farris, L and McDonald, MJ. (2009) Novel fluoroimmunoassay for ovarian cancer biomarker CA-125. Analytical and Bioanalytical Chemistry, 393 (5). p. 1521. ISSN 16182642

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Cancer antigen 125 (CA-125) is a glycoprotein biomarker that denotes the presence of ovarian and reproductive cancers in women, with serum concentrations of CA-125 greater than 35 U/ml considered indicative of potential malignancies. A fluorescent immunoassay recently developed in our laboratory employing the ALYGNSA antibody-orientation system has been used to measure CA-125 levels. This system displayed significantly increased sensitivity with a detection limit of 1.5 U/ml compared to that of a commercial CA-125 enzyme-linked immunosorbent assay (15 U/ml) This tenfold lower level of detection of the ALYGNSA CA-125 assay should permit better identification and monitoring of ovarian cancer.

Item Type: Article
Uncontrolled Keywords: Fluoroimmunoassay; ELISA; Cancer biomarker; CA-125
InterNano Taxonomy: Environment, Health, and Safety > Human Health
Collections: Nanomanufacturing Research Collection > Nanomanufacturing Nanoscale Science and Engineering Centers > Center for High-rate Nanomanufacturing
Nanomanufacturing Research Collection
Depositing User: Danielle Federa
Date Deposited: 16 Jun 2009 17:25
Last Modified: 19 Sep 2011 20:49

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