Sok, Davin and Clarizia, LJ and Farris, L and McDonald, MJ. (2009) Novel fluoroimmunoassay for ovarian cancer biomarker CA-125. Analytical and Bioanalytical Chemistry, 393 (5). p. 1521. ISSN 16182642
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Official URL: http://dx.doi.org/10.1007/s00216-008-2569-8
Abstract
Cancer antigen 125 (CA-125) is a glycoprotein biomarker that denotes the presence of ovarian and reproductive cancers in women, with serum concentrations of CA-125 greater than 35 U/ml considered indicative of potential malignancies. A fluorescent immunoassay recently developed in our laboratory employing the ALYGNSA antibody-orientation system has been used to measure CA-125 levels. This system displayed significantly increased sensitivity with a detection limit of 1.5 U/ml compared to that of a commercial CA-125 enzyme-linked immunosorbent assay (15 U/ml) This tenfold lower level of detection of the ALYGNSA CA-125 assay should permit better identification and monitoring of ovarian cancer.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Fluoroimmunoassay; ELISA; Cancer biomarker; CA-125 |
| InterNano Taxonomy: | Environment, Health, and Safety > Human Health |
| Collections: | Nanomanufacturing Research Collection > Nanomanufacturing Nanoscale Science and Engineering Centers > Center for High-rate Nanomanufacturing Nanomanufacturing Research Collection |
| ID Code: | 100 |
| Deposited By: | Danielle Federa |
| Deposited On: | 16 Jun 2009 13:25 |
| Last Modified: | 19 Sep 2011 16:49 |
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