Multi-Stimuli Sensitive Amphiphilic Block Copolymer Assemblies

Klaikherd, Akamol and Nagamani, C and Thayumanavan, S. (2009) Multi-Stimuli Sensitive Amphiphilic Block Copolymer Assemblies. Journal of the American Chemical Society, 131 (13). p. 4830. ISSN 00027863

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Abstract

Stimuli-responsive polymers are arguably the most widely considered systems for a variety of applications in biomedical arena. We report here a novel triple stimuli sensitive block copolymer assembly that responds to changes in temperature, pH and redox potential. Our block copolymer design constitutes an acid-sensitive THP-protected HEMA as the hydrophobic part and a temperature-sensitive PNIPAM as the hydrophilic part with an intervening disulfide bond. The micellar properties and the release kinetics of the encapsulated guest molecule in response to one stimulus as well as combinations of stimuli have been evaluated. Responsiveness to combination of stimuli not only allows for fine-tuning the guest molecule release kinetics, but also provides the possibility of achieving location-specific delivery.

Item Type: Article
Uncontrolled Keywords: INTRACELLULAR DRUG-DELIVERY; POLYMERIC MICELLES; TRIGGERED RELEASE; BIOENGINEERING APPLICATIONS; SUPRAMOLECULAR ASSEMBLIES; REDUCIBLE POLYCATIONS; N-ISOPROPYLACRYLAMIDE; NONIONIC SURFACTANT; RESPONSIVE POLYMERS; DIBLOCK COPOLYMERS
InterNano Taxonomy: Nanoscale Objects and Nanostructured Materials
Collections: Nanomanufacturing Research Collection
Depositing User: Danielle Federa
Date Deposited: 17 Jun 2009 18:06
Last Modified: 17 Jun 2009 18:06
URI: http://eprints.internano.org/id/eprint/116

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