Functional DNA directed assembly of nanomaterials for biosensing

Wang, Zidong and Lu, Y. (2009) Functional DNA directed assembly of nanomaterials for biosensing. Journal of Materials Chemistry, 19 (13). p. 1788. ISSN 09599428

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Abstract

This review summarizes recent progress in the development of biosensors by integrating functional DNA molecules with different types of nanomaterials, including metallic nanoparticles, semiconductor nanoparticles, magnetic nanoparticles, and carbon nanotubes. On one hand, advances in nanoscale science and technology have generated nanomaterials with unique optical, electrical, magnetic and catalytic properties. On the other hand, recent progress in biology has resulted in functional DNAs, a new class of DNAs that can either bind to a target molecule (known as aptamers) or perform catalytic reactions (known as DNAzymes) with the ability to recognize a broad range of targets from metal ions to organic molecules, proteins and cells specifically. By taking advantage of the strengths in both fields, the physical and chemical properties of nanomaterials have been modulated by the target recognition and catalytic activity of functional DNAs in the presence of a target analyte, resulting in a large number of colorimetric, fluorescent, electrochemical, surface-enhanced Raman scattering and magnetic resonance imaging sensors for the detection of a broad range of analytes with high sensitivity and selectivity.

Item Type: Article
Uncontrolled Keywords: WALLED CARBON NANOTUBES; IRON-OXIDE NANOPARTICLES; FIELD-EFFECT TRANSISTORS; IN-VITRO SELECTION; APTAMER-CONJUGATED NANOPARTICLES; MODIFIED GOLD NANOPARTICLES; ENHANCED RAMAN-SCATTERING; BAND-GAP FLUORESCENCE; SINGLE-STRANDED-DNA; COLORIMETRIC DETECTION
InterNano Taxonomy: Nanomanufacturing Processes > Biological Techniques > DNA templating
Nanoscale Objects and Nanostructured Materials > Nanotubes
Collections: Nanomanufacturing Research Collection
Depositing User: Danielle Federa
Date Deposited: 17 Jun 2009 15:28
Last Modified: 17 Jun 2009 15:28
URI: http://eprints.internano.org/id/eprint/129

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