Centrifugal Sedimentation for Selectively Packing Channels with Silica Microbeads in Three-Dimensional Micro/Nanofluidic Devices

Gong, Maojun and Bohn, PW and Sweedler, JV. (2009) Centrifugal Sedimentation for Selectively Packing Channels with Silica Microbeads in Three-Dimensional Micro/Nanofluidic Devices. Analytical Chemistry, 81 (5). p. 2022. ISSN 00032700

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Abstract

Incorporation of nanofluidic elements into microfluidic channels is one approach for adding filtration and partition functionality to planar microfluidic devices, as well as providing enhanced biomolecular separations. Here we introduce a strategy to pack microfluidic channels with silica nanoparticles and microbeads, thereby indirectly producing functional nanostructures; the method allows selected channels to be packed, here demonstrated so that a separation channel is packed while keeping an injection channel unpacked. A nanocapillary array membrane is integrated between two patterned microfluidic channels that cross each other in vertically separated layers. The membrane serves both as a hit for bead packing and as a fluid communication conduit between microfluidic channels. Centrifugal force-assisted sedimentation is then used to selectively pack the microfluidic channels using an aqueous silica bead suspension loaded into the appropriate inlet reservoirs. This packing approach may be used to simultaneously pack multiple channels with silica microbeads having different sizes and surface properties. The chip design and packing method introduced here are suitable for packing silica particles in sizes ranging from nanometers to micrometers and allow rapid (similar to 10 min) packing with high quality. The liquid/analyte transport characteristics of these packed micro/nanofluidic devices have potential utility in a wide range of applications, including electroosmotic pumping, liquid chromatographic separations, and electrochromatography.

Item Type: Article
Uncontrolled Keywords: NANOCAPILLARY ARRAY MEMBRANES; CAPILLARY ELECTROCHROMATOGRAPHY; MICROFLUIDIC CHANNELS; ELECTROOSMOTIC PUMP; FABRICATION; COLUMNS; SYSTEM; MICROCHIP; CHIP; DNA
InterNano Taxonomy: Nanoscale Objects and Nanostructured Materials > Nanostructured Materials
Nanoscale Objects and Nanostructured Materials > Nanodevice Structures
Nanoscale Objects and Nanostructured Materials > Nanoparticles
Collections: Nanomanufacturing Research Collection > Nanomanufacturing Nanoscale Science and Engineering Centers > Center for Nanoscale Chemical-Electrical-Mechanical Manufacturing Systems
Nanomanufacturing Research Collection
Depositing User: Danielle Federa
Date Deposited: 17 Jun 2009 15:11
Last Modified: 19 Sep 2011 21:10
URI: http://eprints.internano.org/id/eprint/131

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