Stability of quantum dots in live cells

Zhu, Zheng-Jiang and Yeh, Yi-Cheun and Tang, Rui and Yan, Bo and Tamayo, Joshua and Vachet, Richard W. and Rotello, Vincent M.. (2011) Stability of quantum dots in live cells. Nature Chemistry, 3 (12). pp. 963-8.

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Quantum dots are highly fluorescent and photostable, making them excellent tools for imaging. When using these quantum dots in cells and animals, however, intracellular biothiols (such as glutathione and cysteine) can degrade the quantum dot monolayer, compromising function. Here, we describe a label-free method to quantify the intracellular stability of monolayers on quantum dot surfaces that couples laser desorption/ionization mass spectrometry with inductively coupled plasma mass spectrometry. Using this new approach we have demonstrated that quantum dot monolayer stability is correlated with both quantum dot particle size and monolayer structure, with appropriate choice of both particle size and ligand structure required for intracellular stability.

Item Type: Article
InterNano Taxonomy: Nanoscale Objects and Nanostructured Materials > Nanoparticles
Nanoscale Objects and Nanostructured Materials > Nanoparticles > Quantum confinement
Collections: Nanomanufacturing Research Collection > Nanomanufacturing Nanoscale Science and Engineering Centers > Center for Hierarchical Manufacturing
Depositing User: Robert Stevens
Date Deposited: 03 May 2012 18:27
Last Modified: 03 May 2012 18:28

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