Gold nanoparticle-polymer/biopolymer complexes for protein sensing

Moyano, D. F. and Rana, S. and Bunz, U. H. F. and Rotello, V. M.. (2011) Gold nanoparticle-polymer/biopolymer complexes for protein sensing. Faraday Discussions, 152. pp. 33-42. ISSN 1364-5498

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Nanoparticle-based sensor arrays have been used to distinguish a wide range of biomolecular targets through pattern recognition. Such biosensors require selective receptors that generate a unique response pattern for each analyte. The tunable surface properties of gold nanoparticles make these systems excellent candidates for the recognition process. Likewise, the metallic core makes these particles fluorescence superquenchers, facilitating transduction of the binding event. In this report we analyze the role of gold nanoparticles as receptors in differentiating a diversity of important human proteins, and the role of the polymer/biopolymer fluorescent probes for transducing the binding event. A structure-activity relationship analysis of both the probes and the nanoparticles is presented, providing direction for the engineering of future sensor systems.

Item Type: Article
InterNano Taxonomy: Nanoscale Objects and Nanostructured Materials > Nanoparticles
Collections: Nanomanufacturing Research Collection > Nanomanufacturing Nanoscale Science and Engineering Centers > Center for Hierarchical Manufacturing
Depositing User: Robert Stevens
Date Deposited: 19 Apr 2012 21:01
Last Modified: 02 May 2012 17:35

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