Multiplexed Imaging of Nanoparticles in Tissues

Rotello, Vincent M. and Vachet, Richard W.. (2012) Multiplexed Imaging of Nanoparticles in Tissues. Center for Hierarchical Manufacturing. (Unpublished)


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To more fully understand the biodistributions and potential toxicity of nanoparticles (NPs) that are released into the environment, it is essential to monitor the spatial distributions of NPs in vivo. To this end CHM scientists have developed an approach based on laser desorption/ionization mass spectrometry (LDI-MS) to image NPs in tissues. Because MS is used as the readout for this imaging approach, multiple NPs can be imaged simultaneously, which facilitates the side-by-side comparison of different NP types. Results indicate that NPs can remain intact in animals and that biodistribution information can be directly obtained.

Item Type: Other
InterNano Taxonomy: Nanoscale Objects and Nanostructured Materials > Nanoparticles
Collections: Nanomanufacturing Research Collection > Nanomanufacturing Nanoscale Science and Engineering Centers > Center for Hierarchical Manufacturing
Depositing User: Jessica Adamick
Date Deposited: 22 Feb 2013 16:55
Last Modified: 22 Feb 2013 16:55

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