Liu, Q. and Yeh, Y. C. and Rana, S. and Jiang, Y. and Guo, L. J. and Rotello, V. M.. (2013) Differentiation of cancer cell type and phenotype using quantum dot-gold nanoparticle sensor arrays. Cancer Letters, 334 (2). pp. 196-201.
Full text not available from this repository.Abstract
We demonstrate rapid and efficient sensing of mammalian cell types and states using nanoparticle-based sensor arrays. These arrays are comprised of cationic quantum dots (QDs) and gold nanoparticles (AuNPs) that interact with cell surfaces to generate distinguishable fluorescence responses based on cell surface signatures. The use of QDs as the recognition elements as well as the signal transducers presents the potential for direct visualization of selective cell surface interactions. Notably, this sensor is unbiased, precluding the requirement of pre-knowledge of cell state biomarkers and thus providing a general approach for phenotypic profiling of cell states, with additional potential for imaging applications. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Additional Information: | ISI Document Delivery No.: 165OHTimes Cited: 1Cited Reference Count: 36Liu, Qian Yeh, Yi-Cheun Rana, Subinoy Jiang, Ying Guo, Lin Rotello, Vincent M.NSF Center for Hierarchical Manufacturing at the University of Massachusetts CMMI-1025020; NIH GM077173; China scholarship council for the state scholarship fundThis work was supported by the NSF Center for Hierarchical Manufacturing at the University of Massachusetts (CMMI-1025020,), and NIH Grants GM077173. Q. Liu acknowledges support from the China scholarship council for the state scholarship fund.Elsevier ireland ltdClareSi |
| Uncontrolled Keywords: | biomarkers |
| Collections: | Nanomanufacturing Research Collection > Nanomanufacturing Nanoscale Science and Engineering Centers > Center for Hierarchical Manufacturing |
| Depositing User: | Robert Stevens |
| Date Deposited: | 27 Mar 2014 |
| Last Modified: | 27 Mar 2014 20:21 |
| URI: | http://eprints.internano.org/id/eprint/2141 |
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