Nanoparticle-Stabilized Capsules for the Treatment of Bacterial Biofilms

Duncan, B. and Li, X. N. and Landis, R. F. and Kim, S. T. and Gupta, A. and Wang, L. S. and Ramanathan, R. and Tang, R. and Boerth, J. A. and Rotello, V. M.. (2015) Nanoparticle-Stabilized Capsules for the Treatment of Bacterial Biofilms. Acs Nano, 9 (8). pp. 7775-7782.

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Bacterial biofilms are widely associated with persistent infections. High resistance to conventional antibiotics and prevalent virulence makes eliminating these bacterial communities challenging therapeutic targets. We describe here the fabrication of a nanoparticle-stabilized capsule with a multicomponent core for the treatment of biofilms. The peppermint oil and cinnamaldehyde combination that comprises the core of the capsules act as potent antimicrobial agents. An in situ reaction at the oil/water interface between the nanoparticles and cinnamaldehyde structurally augments the capsules to efficiently deliver the essential oil payloads, effectively eradicating biofilms of clinically isolated pathogenic bacteria strains. In contrast to their antimicrobial action, the capsules selectively promoted fibroblast proliferation in a mixed bacteria/mammalian cell system making them promising for wound healing applications.

Item Type: Article
Additional Information: ISI Document Delivery No.: CQ0YATimes Cited: 0Cited Reference Count: 52Duncan, Bradley Li, Xiaoning Landis, Ryan F. Kim, Sung Tae Gupta, Akash Wang, Li-Sheng Ramanathan, Rajesh Tang, Rui Boerth, Jeffrey A. Rotello, Vincent M.Firmenich SA; NIH EB014277; NSF Center for Hierarchical Manufacturing CMMI-1025020This research was supported by Firmenich SA, the NIH (EB014277), and the NSF Center for Hierarchical Manufacturing, CMMI-1025020. Clinical samples obtained from the Cooley Dickinson Hospital Microbiology Laboratory (Northampton, MA) were kindly provided by Dr. Margaret Riley.0Amer chemical socWashington1936-086x
Uncontrolled Keywords: Materials Science
Collections: Nanomanufacturing Research Collection > Nanomanufacturing Nanoscale Science and Engineering Centers > Center for Hierarchical Manufacturing
Depositing User: Robert Stevens
Date Deposited: 12 Nov 2015 18:38
Last Modified: 12 Nov 2015 18:38

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