DNA nanostructures: a shift from assembly to applications

Lanier, L. A. and Bermudez, H.. (2015) DNA nanostructures: a shift from assembly to applications. Current Opinion in Chemical Engineering, 7. pp. 93-100.

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The specificity of DNA hybridization allows for the modular design of 2D and 3D shapes with wide-ranging applications including sensors, actuators, and even logic devices. The inherent biocompatibility of DNA and the ability to produce monodisperse structures of controlled shape and size make DNA nanostructures of interest as potential drug and gene delivery vehicles. In this review, we discuss several new approaches for the assembly of DNA nanostructures, advances in the modeling of these structures, and we highlight recent studies on the use of DNA nanotechnology for therapeutic applications such as drug delivery in tumor models.

Item Type: Article
Additional Information: ISI Document Delivery No.: CM4QXTimes Cited: 0Cited Reference Count: 42Lanier, Laura A. Bermudez, HarryBermudez, Harry/C-8547-2012Bermudez, Harry/0000-0003-0457-5963National Institutes of Health R21 CA158977; National Science Foundation DMR-0847558; NSF Center for Hierarchical Manufacturing CMMI-1025020The authors thank P Charoenphol for helpful discussion. This work was supported by the National Institutes of Health (R21 CA158977), the National Science Foundation (DMR-0847558) and, in part, by the NSF Center for Hierarchical Manufacturing (CMMI-1025020).0Elsevier sci ltdOxford
Uncontrolled Keywords: Engineering
Collections: Nanomanufacturing Research Collection > Nanomanufacturing Nanoscale Science and Engineering Centers > Center for Hierarchical Manufacturing
Depositing User: Robert Stevens
Date Deposited: 12 Nov 2015 18:38
Last Modified: 12 Nov 2015 18:38
URI: http://eprints.internano.org/id/eprint/2325

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