Responsive single-chain polymer nanoparticles with host-guest features

Song, C. F. and Li, L. Y. and Dai, L. Z. and Thayumanavan, S.. (2015) Responsive single-chain polymer nanoparticles with host-guest features. Polymer Chemistry, 6 (26). pp. 4828-4834.

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We report a facile approach to form ultra-fine single-chain polymer nanoparticles (SCPNs) via disulfide-based intrachain crosslinking of single polymer chains of a random copolymer poly(HEMA-co-PDSEMA). The SCPNs, which were prepared under mild reaction conditions and at normal reaction concentrations (up to 10 mg mL(-1)), have been characterized by H-1 nuclear magnetic resonance (H-1 NMR) spectroscopy, atomic force microscopy (AFM), differential scanning calorimetry (DSC), gel permeation chromatography (GPC), and dynamic light scattering (DLS). The influences of the crosslinking density, the molecular weight and the initial concentration of the polymer upon the formation of SCPNs are also reported. In order to investigate the hydrophobic interior of SCPNs, we trace the emission spectrum of a pyrene probe. We highlight that these SCPNs exhibit host-guest properties to stably encapsulate hydrophobic guest molecules and release them in response to a redox stimulus.

Item Type: Article
Additional Information: ISI Document Delivery No.: CL1JZTimes Cited: 0Cited Reference Count: 43Song, Cunfeng Li, Longyu Dai, Lizong Thayumanavan, S.U.S. National Science Foundation CHE-1307118; National Natural Science Foundation of China U1205113; Center for Hierarchical Manufacturing CMMI-1025020We thank the U.S. National Science Foundation (CHE-1307118) and the National Natural Science Foundation of China (U1205113) for support. We also thank the Center for Hierarchical Manufacturing for partial support (CMMI-1025020). We thank Shirong Yu for help with the schematic representations.0Royal soc chemistryCambridge1759-9962
Uncontrolled Keywords: Polymer Science
Collections: Nanomanufacturing Research Collection > Nanomanufacturing Nanoscale Science and Engineering Centers > Center for Hierarchical Manufacturing
Depositing User: Robert Stevens
Date Deposited: 12 Nov 2015 18:38
Last Modified: 12 Nov 2015 18:38

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