Zhu, Zheng-Jiang and Ghosh, Partha S. and Miranda, Oscar R. and Vachet, Richard W. and Rotello, Vincent M.. (2008) Multiplexed Screening of Cellular Uptake of Gold Nanoparticles Using Laser Desorption/Ionization Mass Spectrometry. Journal of the American Chemical Society, 130 (43). pp. 14139-14143. ISSN 0002-7863
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Official URL: http://dx.doi.org/10.1021/ja805392f
Abstract
Gold nanoparticles (AuNPs) are highly promising candidates as drug delivery agents into cells of interest. We describe for the first time the multiplexed analysis of nanoparticle uptake by cells using mass spectrometry. We demonstrate that the cellular uptake of functionalized gold nanoparticles with cationic or neutral surface ligands can be readily determined using laser desorption/ionization mass spectrometry of cell lysates. The surface ligands have “mass barcodes” that allow different nanoparticles to be simultaneously identified and quantified at levels as low as 30 pmol. Using this method, we find that subtle changes to AuNP surface functionalities can lead to measurable changes in cellular uptake propensities.
| Item Type: | Article |
|---|---|
| Additional Information: | Reprinted with permission from "Multiplexed Screening of Cellular Uptake of Gold Nanoparticles Using Laser Desorption/Ionization Mass Spectrometry", Z-J Zhu et al, Journal of the Ameerican Chemical Society. Copyright 2008 American Chemical Society. |
| InterNano Taxonomy: | Nanomanufacturing Characterization Techniques > Other Characterization Techniques > Mass spectrometry Nanomanufacturing Processes > Self Assembly > Self-assembled monolayers (SAM) Nanoscale Objects and Nanostructured Materials > Nanoparticles |
| Collections: | Nanomanufacturing Research Collection |
| ID Code: | 265 |
| Deposited By: | Moureen Kemei |
| Deposited On: | 08 Feb 2010 15:30 |
| Last Modified: | 08 Feb 2010 15:30 |
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