Molecular discrimination inside polymer nanotubules

Savariar, Elamprakash N. and Krishnamoorthy, K. and Thayumanavan, S.. (2008) Molecular discrimination inside polymer nanotubules. Nature Nanotechnology, 3 (2). pp. 112-117. ISSN 1748-3387

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Recognition of small organic molecules and large biomolecules such as proteins is of great importance in pharmaceutical as well as biological applications. Recognition inside a nanoporous membrane is particularly attractive, because of the advantages associated with ligand–receptor interactions in confined spaces. Classical nanoporous membrane-based separations simply use the difference in size of the analytes relative to pore size in the membrane. In order to bring about selectivity beyond size, it is necessary that methods for functionalizing the membrane pores are readily available. Here, we describe a simple approach to functionalize the nanopores within these membranes using self-assembling and non-self-assembling polymers. We show that these modified membranes separate small molecules based on size, charge and hydrophobicity. We also demonstrate here that proteins can be differentially transported through the nanopores based on their size and/or electrostatics.

Item Type: Article
Additional Information: Reprinted by permission from Macmillan Publishers Ltd: [Nature Nanotechnology] ("Molecular discrimination inside polymer nanotubules", E. N. Savariar et al.), copyright (2008)
InterNano Taxonomy: Nanomanufacturing Processes > Self Assembly
Nanomanufacturing Processes > Assembly Techniques > Surface-to-surface transfer
Nanoscale Objects and Nanostructured Materials > Nanocomposites > Polymeric
Collections: Nanomanufacturing Research Collection > Nanomanufacturing Nanoscale Science and Engineering Centers > Center for Hierarchical Manufacturing
Nanomanufacturing Research Collection
Depositing User: Moureen Kemei
Date Deposited: 08 Feb 2010 22:17
Last Modified: 19 Sep 2011 21:33

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