Effect of pharmaceuticals on thermoreversible gelation of PEO–PPO–PEO copolymers

SHARMA, P and REILLY, M and BHATIA, S and SAKHITAB, N and ARCHAMBAULT, J and BHATIA, S. (2008) Effect of pharmaceuticals on thermoreversible gelation of PEO–PPO–PEO copolymers. Colloids and Surfaces B: Biointerfaces, 63 (2). pp. 229-235. ISSN 09277765

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Pluronic F127, a triblock copolymer of poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO), has generated considerable interest as a drug delivery vehicle due to its ability to gel at physiological temperatures. This work examines the gelation behavior of Pluronic F127 in the presence of a series of hydrophobic pharmaceuticals, to determine whether there is any correlation between gelation and physicochemical parameters of drug solutes. The study includes the local anesthetics dibucaine, lidocaine, and tetracaine; the pharmaceutical additives methyl paraben, ethyl paraben, and propyl paraben; the anti-cancer agents paclitaxel and baccatin III; and the anti-inflammatory agent sulindac. The results indicate that the presence of local anesthetics and pharmaceutical additives allows F127 solutions to form gels at lower copolymer concentrations; local anesthetics and pharmaceutical additives also shift gelation down to a lower gelation temperature. This behavior is strongly dependent on drug solubility; poorly soluble drugs (paclitaxel, baccatin III, sulindac) do not change the lower gelation temperature or minimum F127 concentration for gelation. An equation relating the decrease in gelation temperature to drug solubility is presented, and the equation fits the data well. The results have significant positive implications on the toxicity and economic issues related to use of Pluronic F127 in drug delivery.

Item Type: Article
InterNano Taxonomy: Nanoscale Objects and Nanostructured Materials > Nanostructured Materials > Block copolymers
Nanomanufacturing Characterization Techniques > Mechanical Property Characterization
Nanomanufacturing Characterization Techniques
Environment, Health, and Safety > Human Health > Toxicology
Collections: Nanomanufacturing Research Collection > Nanomanufacturing Nanoscale Science and Engineering Centers > Center for Hierarchical Manufacturing
Nanomanufacturing Research Collection
Depositing User: Moureen Kemei
Date Deposited: 16 Feb 2010 19:52
Last Modified: 19 Sep 2011 21:06
URI: http://eprints.internano.org/id/eprint/274

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