Samanta, Bappaditya and Yan, Haoheng and Fischer, Nicholas O. and Shi, Jing and Jerry, D. Joseph and Rotello, Vincent M.. (2008) Protein-passivated Fe3O4 nanoparticles: low toxicity and rapid heating for thermal therapy. Journal of Materials Chemistry, 18 (11). pp. 1204-1208. ISSN 0959-9428
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Official URL: http://dx.doi.org/10.1039/b718745a
Abstract
Thermotherapy is a promising technique for the minimally invasive elimination of solid tumors. Here we report the fabrication of protein-coated iron oxide NPs (12 nm core) for use as thermal therapeutic agents. These albumin-passivated NPs are stable under physiological conditions, with rapid heating and cell killing capacity upon alternating magnetic field (AMF) exposure. The mode of action is specific: no measurable cytotoxicity was observed for the particle without AMF or for AMF exposure without the particle.
| Item Type: | Article |
|---|---|
| InterNano Taxonomy: | Nanomanufacturing Processes > Biological Techniques > Protein assembly Nanomanufacturing Processes > Biological Techniques Nanoscale Objects and Nanostructured Materials > Nanoparticles |
| Collections: | Nanomanufacturing Research Collection |
| ID Code: | 289 |
| Deposited By: | Moureen Kemei |
| Deposited On: | 17 Feb 2010 16:34 |
| Last Modified: | 17 Feb 2010 16:34 |
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