Efficient Gene Delivery Vectors by Tuning the Surface Charge Density of Amino Acid-Functionalized Gold Nanoparticles

Ghosh, Partha S. and Kim, Chae-Kyu and Han, Gang and Forbes, Neil S. and Rotello, Vincent M.. (2008) Efficient Gene Delivery Vectors by Tuning the Surface Charge Density of Amino Acid-Functionalized Gold Nanoparticles. ACS Nano, 2 (11). pp. 2213-2218. ISSN 1936-0851

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Abstract

Gold colloids functionalized with amino acids provide a scaffold for effective DNA binding with subsequent condensation. Particles with lysine and lysine dendron functionality formed particularly compact complexes and provided highly efficient gene delivery without any observed cytotoxicity. Nanoparticles functionalized with first generation lysine dendrons (NP−LysG1) were 28-fold superior to polylysine in reporter gene expression. These amino acid-based nanoparticles were responsive to intracellular glutathione levels, providing a tool for controlled release and concomitant expression of DNA.

Item Type: Article
Additional Information: Reprinted with permission from "Efficient Gene Delivery Vectors by Tuning the Surface Charge Density of Amino Acid-Functionalized Gold Nanoparticles", V Rotello et al., ACS nano, 2(11), pg 2213-2218. Copyright 2008 American Chemical Society.
InterNano Taxonomy: Nanomanufacturing Processes > Self Assembly > Chemical surface functionalization
Nanoscale Objects and Nanostructured Materials
Nanomanufacturing Processes > Biological Techniques
Nanoscale Objects and Nanostructured Materials > Nanoparticles
Collections: Nanomanufacturing Research Collection > Nanomanufacturing Nanoscale Science and Engineering Centers > Center for Hierarchical Manufacturing
Nanomanufacturing Research Collection
Depositing User: Moureen Kemei
Date Deposited: 22 Feb 2010 16:03
Last Modified: 19 Sep 2011 21:31
URI: http://eprints.internano.org/id/eprint/297

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