HWANG, J and LI, R and MAYNARD, H. (2007) Well-defined polymers with activated ester and protected aldehyde side chains for bio-functionalization. Journal of Controlled Release, 122 (3). pp. 279-286. ISSN 01683659
Full text not available from this repository. (Request a copy)Abstract
Polymers with reactive side chains and narrow molecular weight distributions were synthesized by reversible addition-fragmentation chain transfer (RAFT) polymerization, and the potential to utilize these polymers to prepare drug carriers was demonstrated. p-Nitrophenyl methacrylate (NPMA) and diethoxypropyl methacrylate (DEPMA) were polymerized utilizing cumyl dithiobenzoate (CDB) as the chain transfer agent and azobisisobutyronitrile (AIBN) as the initiator to high conversions (≥ 86%). The resulting pNPMA and pDEPMA had narrow molecular weight distributions (polydispersity indices < 1.3). The ability to functionalize these polymers was confirmed. For pNPMA, up to 86% of the side chains were substituted with the amino acid, glycine methyl ester. The side chains of pDEPMA were hydrolyzed to aldehydes and reaction with O-benzylhydroxylamine and O-methylhydroxylamine to form stable oxime bond conjugates was demonstrated. The percent substitution depended on the feed ratios. Conjugation of an aminooxy-functionalized RGD peptide was also demonstrated.
Item Type: | Article |
---|---|
InterNano Taxonomy: | Nanoscale Objects and Nanostructured Materials > Nanostructured Materials > Block copolymers Nanomanufacturing Processes > Biological Techniques |
Collections: | Nanomanufacturing Research Collection > Nanomanufacturing Nanoscale Science and Engineering Centers > Center for Scalable and Integrated Nanomanufacturing |
Depositing User: | Moureen Kemei |
Date Deposited: | 31 Mar 2010 21:54 |
Last Modified: | 26 Sep 2014 21:12 |
URI: | http://eprints.internano.org/id/eprint/397 |
Actions (login required)
View Item |