Induction of Cell Death by Magnetic Actuation of Nickel Nanowires Internalized by Fibroblasts

Fung, Andrew O. and Kapadia, Vishal and Pierstorff, Erik and Ho, Dean and Chen, Yong. (2008) Induction of Cell Death by Magnetic Actuation of Nickel Nanowires Internalized by Fibroblasts. Journal of Physical Chemistry C, 112 (39). pp. 15085-15088. ISSN 1932-7447

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Abstract

Magnetic nanomaterials with multimodal functionalities have emerged as a versatile platform for biomedical applications that range from basic cellular interrogation to clinical nanomedicine. In this work, we have prepared electrodeposited ferromagnetic nickel nanowires for efficient internalization into 3T3 fibroblasts. Agitation of the nanowires by a low external field induced cell death, as assessed by MTT viability assays. The response of the interleukin-6 (IL-6) gene expression of the fibroblasts to nanowire-mediated cellular manipulation was examined by quantitative real-time polymerase chain reaction (qRT-PCR). These nanowires exhibited significant potential as therapeutic and interrogative platforms for biomedicine.

Item Type: Article
Additional Information: Reprinted with permission from "Induction of Cell Death by Magnetic Actuation of Nickel Nanowires Internalized by Fibroblasts", Fung A et al., J. Phys. Chem. C, 2008, 112 (39), pp 15085–15088. Copyright 2008 American Chemical Society
Uncontrolled Keywords: Nanomedicine
InterNano Taxonomy: Nanoscale Objects and Nanostructured Materials > Nanocomposites > Magnetic
Nanoscale Objects and Nanostructured Materials > Nanowires
Collections: Nanomanufacturing Research Collection
Depositing User: Moureen Kemei
Date Deposited: 09 Apr 2010 14:28
Last Modified: 09 Apr 2010 14:28
URI: http://eprints.internano.org/id/eprint/417

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