Ultrananocrystalline Diamond Thin Films Functionalized with Therapeutically Active Collagen Networks

Huang, Houjin and Chen, Mark and Bruno, Paola and Lam, Robert and Robinson, Erik and Gruen, Dieter and Ho, Dean. (2009) Ultrananocrystalline Diamond Thin Films Functionalized with Therapeutically Active Collagen Networks. The Journal of Physical Chemistry B, 113 (10). pp. 2966-2971. ISSN 1520-6106

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Abstract

The fabrication of biologically amenable interfaces in medicine bridges translational technologies with their surrounding biological environment. Functionalized nanomaterials catalyze this coalescence through the creation of biomimetic and active substrates upon which a spectrum of therapeutic elements can be delivered to adherent cells to address biomolecular processes in cancer, inflammation, etc. Here, we demonstrate the robust functionalization of ultrananocrystalline diamond (UNCD) with type I collagen and dexamethasone (Dex), an anti-inflammatory drug, to fabricate a hybrid therapeutically active substrate for localized drug delivery. UNCD oxidation coupled with a pH-mediated collagen adsorption process generated a comprehensive interface between the two materials, and subsequent Dex integration, activity, and elution were confirmed through inflammatory gene expression assays. These studies confer a translational relevance to the biofunctionalized UNCD in its role as an active therapeutic network for potent regulation of cellular activity toward applications in nanomedicine.

Item Type: Article
Additional Information: Reprinted with permission from "Ultrananocrystalline Diamond Thin Films Functionalized with Therapeutically Active Collagen Networks", Huang H et al., J. Phys. Chem. B, 2009, 113 (10), pp 2966–2971. Copyright 2009 American Chemical Society
Uncontrolled Keywords: NECROSIS-FACTOR-ALPHA; TUMOR-NECROSIS; DRUG-DELIVERY; IN-VITRO; KAPPA-B; FLUORESCENT NANODIAMONDS; CARBON NANOTUBES; PROSTATE-CANCER; INTERLEUKIN-6; PH
InterNano Taxonomy: Nanomanufacturing Processes > Self Assembly > Chemical surface functionalization
Areas of Application > Medical and Pharmaceutical Industries
Nanoscale Objects and Nanostructured Materials > Nanocomposites > Thin films
Nanoscale Objects and Nanostructured Materials > Nanocomposites
Nanoscale Objects and Nanostructured Materials > Nanoparticles > Nanodiamonds
Collections: Nanomanufacturing Research Collection
Depositing User: Moureen Kemei
Date Deposited: 12 Apr 2010 21:44
Last Modified: 19 Sep 2011 21:21
URI: http://eprints.internano.org/id/eprint/428

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