Bajaj, A. and Miranda, O. R. and Kim, I.-B. and Phillips, R. L. and Jerry, D. J. and Bunz, U. H. F. and Rotello, V. M.. (2009) Detection and differentiation of normal, cancerous, and metastatic cells using nanoparticle-polymer sensor arrays. Proceedings of the National Academy of Sciences, 106 (27). pp. 10912-10916. ISSN 0027-8424
Full text not available from this repository. (Request a copy)Abstract
Rapid and effective differentiation between normal and cancer cells is an important challenge for the diagnosis and treatment of tumors. Here, we describe an array-based system for identification of normal and cancer cells based on a “chemical nose/tongue” approach that exploits subtle changes in the physicochemical nature of different cell surfaces. Their differential interactions with functionalized nanoparticles are transduced through displacement of a multivalent polymer fluorophore that is quenched when bound to the particle and fluorescent after release. Using this sensing strategy we can rapidly (minutes/seconds) and effectively distinguish (i) different cell types; (ii) normal, cancerous and metastatic human breast cells; and (iii) isogenic normal, cancerous and metastatic murine epithelial cell lines.
Item Type: | Article |
---|---|
Uncontrolled Keywords: | oncology, gold nanoparticle, biosensor, conjugated polymer, fluorophore, array-based system |
InterNano Taxonomy: | Nanoscale Objects and Nanostructured Materials Areas of Application > Medical and Pharmaceutical Industries Nanoscale Objects and Nanostructured Materials > Nanoparticles Tool development |
Collections: | Nanomanufacturing Research Collection > Nanomanufacturing Nanoscale Science and Engineering Centers > Center for Hierarchical Manufacturing Nanomanufacturing Research Collection |
Related URLs: | |
Depositing User: | Mr. Richard L Rosen |
Date Deposited: | 08 Jun 2010 14:52 |
Last Modified: | 19 Sep 2011 21:43 |
URI: | http://eprints.internano.org/id/eprint/474 |
Actions (login required)
View Item |