Detection and differentiation of normal, cancerous, and metastatic cells using nanoparticle-polymer sensor arrays

Bajaj, A. and Miranda, O. R. and Kim, I.-B. and Phillips, R. L. and Jerry, D. J. and Bunz, U. H. F. and Rotello, V. M.. (2009) Detection and differentiation of normal, cancerous, and metastatic cells using nanoparticle-polymer sensor arrays. Proceedings of the National Academy of Sciences, 106 (27). pp. 10912-10916. ISSN 0027-8424

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Abstract

Rapid and effective differentiation between normal and cancer cells is an important challenge for the diagnosis and treatment of tumors. Here, we describe an array-based system for identification of normal and cancer cells based on a “chemical nose/tongue” approach that exploits subtle changes in the physicochemical nature of different cell surfaces. Their differential interactions with functionalized nanoparticles are transduced through displacement of a multivalent polymer fluorophore that is quenched when bound to the particle and fluorescent after release. Using this sensing strategy we can rapidly (minutes/seconds) and effectively distinguish (i) different cell types; (ii) normal, cancerous and metastatic human breast cells; and (iii) isogenic normal, cancerous and metastatic murine epithelial cell lines.

Item Type: Article
Uncontrolled Keywords: oncology, gold nanoparticle, biosensor, conjugated polymer, fluorophore, array-based system
InterNano Taxonomy: Nanoscale Objects and Nanostructured Materials
Areas of Application > Medical and Pharmaceutical Industries
Nanoscale Objects and Nanostructured Materials > Nanoparticles
Tool development
Collections: Nanomanufacturing Research Collection > Nanomanufacturing Nanoscale Science and Engineering Centers > Center for Hierarchical Manufacturing
Nanomanufacturing Research Collection
Related URLs:
Depositing User: Mr. Richard L Rosen
Date Deposited: 08 Jun 2010 14:52
Last Modified: 19 Sep 2011 21:43
URI: http://eprints.internano.org/id/eprint/474

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