caNanoLab Overview

Gaheen, Sharon. (2010) caNanoLab Overview. In: Nanoinformatics 2010, November 3 - 5, 2010, Arlington, VA. (Unpublished)

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Abstract

The application of nanotechnology in cancer promises advancements in early detection, targeted therapeutics, and cancer prevention and control. The use of nanotechnology in biomedicine involves the engineering of nanomaterials to act as therapeutic carriers, targeting agents, and diagnostic imaging devices. To assist in expediting and validating the use of nanomaterials in biomedicine, the NCI Center for Biomedical Informatics and Information Technology (CBIIT), in collaboration with the NCI Nanotechnology Characterization Laboratory (NCL) and other Cancer Centers of Nanotechnology Excellence (CCNEs), has developed a data sharing portal called caNanoLab (http://cananolab.nci.nih.gov/caNanoLab/). caNanoLab provides access to experimental and literature-curated data from the NCL and other CCNEs and facilitates data sharing via the use of caBIG(r) technologies enabling semantic interoperability. caNanoLab provides a model for representing the composition of nanomaterial types (dendrimer, carbon nanotube) and associated functionalizing entities (e.g. small molecules, antibodies). caNanoLab supports the annotation of nanomaterials with characterizations resulting from physico-chemical (size, molecular weight) and in vitro (cytotoxicity, immunotoxicity) assays and the sharing of these characterizations and associated protocols in a secure fashion. The caNanoLab project is expanding to include support for in vivo characterizations (pharmacokinetics, toxicology) of nanomaterials. To represent nanomaterials and associated characterizations, caNanoLab leverages concepts from the NCI's Enterprise Vocabulary Services (EVS) and the Nanomaterial Ontology (NPO) designed by Washington University. The caNanoLab project is collaborating with members of the biomedical nanotechnology community through the caBIG(r) Nano WG in the development of nano-TAB, a standard supporting data import/export between disparate nanotechnology systems.

Item Type: Conference or Workshop Item (Paper)
Uncontrolled Keywords: nanomedicine, caNanoLab, cancer research, in vivo, in vitro,
InterNano Taxonomy: Areas of Application > Medical and Pharmaceutical Industries
Informatics and Standards
Collections: National Nanomanufacturing Network Archive > Conferences and Workshops > Nanoinformatics 2010
Depositing User: Rebecca Reznik-Zellen
Date Deposited: 11 Mar 2011 22:31
Last Modified: 11 Mar 2011 22:37
URI: http://eprints.internano.org/id/eprint/573

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