Surface Functionality of Nanoparticles Determines Cellular Uptake Mechanisms in Mammalian Cells

Saha, K. and Kim, S. T. and Yan, B. and Miranda, O. R. and Alfonso, F. S. and Shlosman, D. and Rotello, V. M.. (2013) Surface Functionality of Nanoparticles Determines Cellular Uptake Mechanisms in Mammalian Cells. Small, 9 (2). pp. 300-305.

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Abstract

Nanoparticles (NPs) are versatile scaffolds for numerous biomedical applications including drug delivery and bioimaging. The surface functionality of NPs essentially dictates intracellular NP uptake and controls their therapeutic action. Using several pharmacological inhibitors, it is demonstrated that the cellular uptake mechanisms of cationic gold NPs in both cancer (HeLa) and normal cells (MCF10A) strongly depend on the NP surface monolayer, and mostly involve caveolae and dynamin-dependent pathways as well as specific cell surface receptors (scavenger receptors). Moreover, these NPs show different uptake mechanisms in cancer and normal cells, providing an opportunity to develop NPs with improved selectivity for delivery applications.

Item Type: Article
Additional Information: Times Cited: 0Saha, Krishnendu Kim, Sung Tae Yan, Bo Miranda, Oscar R. Alfonso, Felix S. Shlosman, Denis Rotello, Vincent M.
Collections: Nanomanufacturing Research Collection > Nanomanufacturing Nanoscale Science and Engineering Centers > Center for Hierarchical Manufacturing
Depositing User: Robert Stevens
Date Deposited: 27 Mar 2014
Last Modified: 27 Mar 2014 20:21
URI: http://eprints.internano.org/id/eprint/2205

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