Quantum Dot Stability in Cells is Size Dependent

Rotello, Vincent M. and Vachet, Richard W.. Center for Hierarchical Manufacturing. (2012) Quantum Dot Stability in Cells is Size Dependent. Center for Hierarchical Manufacturing. (Unpublished)


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Quantum dots (QDs) are highly fluorescent and photostable, making them excellent tools for imaging. When using these QDs in cells and animals, however, intracellular biothiols can degrade the QD monolayer compromising function. CHM scientists have developed a label-free method to quantify the intracellular stability of monolayers on QD surfaces that couples laser desorption/ionization mass spectrometry (LDI-MS) with inductively coupled plasma mass spectrometry (ICP-MS). Using this new approach they have demonstrated that QD monolayer stability is correlated with both QD particle size and monolayer structure, with proper choice of both particle size and ligand structure required for intracellular stability.

Item Type: Other
Collections: Nanomanufacturing Research Collection > Nanomanufacturing Nanoscale Science and Engineering Centers > Center for Hierarchical Manufacturing
Depositing User: Jessica Adamick
Date Deposited: 05 Oct 2012 18:19
Last Modified: 05 Oct 2012 18:19
URI: http://eprints.internano.org/id/eprint/1860

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