Sub-micrometer Patterning of Proteins by Electric Lithography

Chang, Yu and Ahn, Yong Sik and Hahn, H. Thomas and Chen, Yong. (2007) Sub-micrometer Patterning of Proteins by Electric Lithography. Langmuir, 23 (8). pp. 4112-4114. ISSN 0743-7463

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We report in this paper an electric lithographic (EL) technique to generate protein patterns with sub-micrometer resolution on a poly(N-tBOC-2-aminoethyl methacrylate) surface. In the EL process, an electric potential is applied between metal patterns on a mask and the poly(N-tBOC-2-aminoethyl methacrylate) layer to electrochemically induce the dissociation of the tBOC from the amine functional groups. Proteins are then selectively attached to the amine functional groups in the modified polymer surface areas to form protein patterns. This technique can reliably generate high-resolution protein patterns down to 300 nm on the polymer surface at a high speed with a simple process/system.

Item Type: Article
Additional Information: Reprinted with permission from "Sub-micrometer Patterning of Proteins by Electric Lithography", Chang Y et al., Langmuir, 2007, 23 (8), pp 4112–4114. Copyright 2007 American Chemical Society.
InterNano Taxonomy: Nanomanufacturing Processes > Biological Techniques > Protein assembly
Nanomanufacturing Processes > Nanopatterning/Lithography
Collections: Nanomanufacturing Research Collection > Nanomanufacturing Nanoscale Science and Engineering Centers > Center for Scalable and Integrated Nanomanufacturing
Depositing User: Moureen Kemei
Date Deposited: 31 Mar 2010 19:33
Last Modified: 26 Sep 2014 21:08

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