Placement and orientation of individual DNA shapes on lithographically patterned surfaces

Kershner, Ryan J. and Bozano, Luisa D. and Micheel, Christine M. and Hung, Albert M. and Fornof, Ann R. and Cha, Jennifer N. and Rettner, Charles T. and Bersani, Marco and Frommer, Jane and Rothemund, Paul W. K. and Wallraff, Gregory M.. (2009) Placement and orientation of individual DNA shapes on lithographically patterned surfaces. Nature Nanotechnology, 4 (9). pp. 557-561. ISSN 1748-3387

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Artificial DNA nanostructures show promise for the organization of functional materials to create nanoelectronic5 or nano-optical devices. DNA origami, in which a long single strand of DNA is folded into a shape using shorter staple strands can display 6-nm-resolution patterns of binding sites, in principle allowing complex arrangements of carbon nanotubes, silicon nanowires, or quantum dots. However, DNA origami are synthesized in solution and uncontrolled deposition results in random arrangements; this makes it difficult to measure the properties of attached nanodevices or to integrate them with conventionally fabricated microcircuitry. Here we describe the use of electron-beam lithography and dry oxidative etching to create DNA origami-shaped binding sites on technologically useful materials, such as SiO2 and diamond-like carbon. In buffer with approx100 mM MgCl2, DNA origami bind with high selectivity and good orientation: 70–95% of sites have individual origami aligned with an angular dispersion (plus minus 1 s.d.) as low as plus minus 10° (on diamond-like carbon) or plus minus 20° (on SiO2).

Item Type: Article
Additional Information: Abstract reprinted by permission from MacMillan Publishers Ltd. Copyright 2009.
Uncontrolled Keywords: DNA nanostructures, self-assembled nanostructures, DNA origami, carbon nanotubes
InterNano Taxonomy: Nanoscale Objects and Nanostructured Materials > Nanostructured Materials
Nanomanufacturing Processes > Biological Techniques > Protein assembly
Nanoscale Objects and Nanostructured Materials > Other Nanostructured Materials > Self assembled monolayers
Nanomanufacturing Processes > Nanopatterning/Lithography
Nanomanufacturing Processes > Nanopatterning/Lithography > Electron-beam lithography
Nanoscale Objects and Nanostructured Materials > Nanotubes > Carbon nanotubes
Collections: Nanomanufacturing Research Collection
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Depositing User: Mr. Richard L Rosen
Date Deposited: 15 Jun 2010 18:35
Last Modified: 15 Jun 2010 18:35

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