Designing electrospun nanofiber mats to promote wound healing - a review

Rieger, K. A. and Birch, N. P. and Schiffman, J. D.. (2013) Designing electrospun nanofiber mats to promote wound healing - a review. Journal of Materials Chemistry B, 1 (36). pp. 4531-4541.

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Abstract

Current strategies to treat chronic wounds offer limited relief to the 7.75 million patients who suffer from burns or chronic skin ulcers. Thus, as long as chronic wounds remain a global healthcare problem, the development of alternate treatments remain desperately needed. This review explores the recent strategies employed to tailor electrospun nanofiber mats towards accelerating the wound healing process. Porous nanofiber mats readily produced by the electrospinning process offer a promising solution to the management of wounds. The matrix chemistry, surface functionality, and mat degradation rate all can be fine-tuned to govern the interactions that occur at the materials-biology interface. In this review, first we briefly discuss the wound healing process and then highlight recent advances in drug release, biologics encapsulation, and antibacterial activity that have been demonstrated via electrospinning. While this versatile biomaterial has shown much progress, commercializing nanofiber mats that fully address the needs of an individual patient remains an ambitious challenge.

Item Type: Article
Additional Information: ISI Document Delivery No.: 205ZLTimes Cited: 0Cited Reference Count: 124Rieger, Katrina A. Birch, Nathan P. Schiffman, Jessica D.NSF DGE-0654128; NSF Center for Hierarchical Manufacturing at the University of Massachusetts (NSEC) CMMI-1025020KAR would like to thank the NSF-sponsored Institute for Cellular Engineering IGERT program (DGE-0654128). This work was supported by the NSF Center for Hierarchical Manufacturing at the University of Massachusetts (NSEC, CMMI-1025020).Royal soc chemistryCambridge
Uncontrolled Keywords: biologic dressings
Collections: Nanomanufacturing Research Collection > Nanomanufacturing Nanoscale Science and Engineering Centers > Center for Hierarchical Manufacturing
Depositing User: Robert Stevens
Date Deposited: 27 Mar 2014
Last Modified: 27 Mar 2014 20:21
URI: http://eprints.internano.org/id/eprint/2162

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