Marsico, A. L. M. and Creran, B. and Duncan, B. and Elci, S. G. and Jiang, Y. and Onasch, T. B. and Wormhoudt, J. and Rotello, V. M. and Vachet, R. W.. (2015) Inkjet-Printed Gold Nanoparticle Surfaces for the Detection of Low Molecular Weight Biomolecules by Laser Desorption/Ionization Mass Spectrometry. Journal of the American Society for Mass Spectrometry, 26 (11). pp. 1931-1937.
Full text not available from this repository.Abstract
Effective detection of low molecular weight compounds in matrix-assisted laser desorption/ionization (MALDI) mass spectrometry (MS) is often hindered by matrix interferences in the low m/z region of the mass spectrum. Here, we show that monolayer-protected gold nanoparticles (AuNPs) can serve as alternate matrices for the very sensitive detection of low molecular weight compounds such as amino acids. Amino acids can be detected at low fmol levels with minimal interferences by properly choosing the AuNP deposition method, density, size, and monolayer surface chemistry. By inkjet-printing AuNPs at various densities, we find that AuNP clusters are essential for obtaining the greatest sensitivity.
| Item Type: | Article |
|---|---|
| Additional Information: | ISI Document Delivery No.: CT6XCTimes Cited: 0Cited Reference Count: 45Marsico, Alyssa L. M. Creran, Brian Duncan, Bradley Elci, S. Gokhan Jiang, Ying Onasch, Timothy B. Wormhoudt, Joda Rotello, Vincent M. Vachet, Richard W.NSF CMMI-1025020; SBIR from NASA NNX12CG18PThe authors acknowledge support for this work by the NSF (CMMI-1025020) and the SBIR grant NNX12CG18P from NASA.0SpringerNew york1879-1123 |
| Uncontrolled Keywords: | Spectroscopy |
| Collections: | Nanomanufacturing Research Collection > Nanomanufacturing Nanoscale Science and Engineering Centers > Center for Hierarchical Manufacturing |
| Depositing User: | Robert Stevens |
| Date Deposited: | 12 Nov 2015 18:38 |
| Last Modified: | 12 Nov 2015 18:38 |
| URI: | http://eprints.internano.org/id/eprint/2332 |
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