Hu, G. J. and Parelkar, S. S. and Emrick, T.. (2015) A facile approach to hydrophilic, reverse zwitterionic, choline phosphate polymers. Polymer Chemistry, 6 (4). pp. 525-530.
Full text not available from this repository.Abstract
2-{2-(Methacryloyloxy) ethyldimethylammonium}ethyl n-butyl phosphate (MBP) was synthesized and polymerized by controlled free radical methods to afford a new set of ``reverse zwitterionic'' choline phosphate (CP) substituted polymers. The synthesis overcomes prior limitations associated with related CP-methacrylates, affording facile access to MBP homopolymers and MBP-containing diblock copolymers. Dynamic light scattering revealed the size of polyMBP in water, while cell culture assays showed polyMBP to have excellent biocompatibility and non-immunogenicity. The facile synthesis of MBP monomer, and the corresponding polymers, opens a new platform towards a diverse set of functional, hydrophilic biocompatible polymers.
| Item Type: | Article |
|---|---|
| Additional Information: | ISI Document Delivery No.: AX4RSTimes Cited: 0Cited Reference Count: 44Hu, Gaojie Parelkar, Sangram S. Emrick, ToddCenter for Hierarchical Manufacturing (CHM) at UMass Amherst CMMI-10205020; National Institutes of Health for the evaluation of polymer zwitterion compatibility R21 CA167674The authors gratefully acknowledge funding from the Center for Hierarchical Manufacturing (CHM) at UMass Amherst (CMMI-10205020) and the National Institutes of Health for the evaluation of polymer zwitterion compatibility with cells (R21 CA167674). The authors also acknowledge Dr Sallie Schneider and Dr Kelly Gauger for providing mice spleens from the Pioneer Valley Life Sciences Institute.0Royal soc chemistryCambridge1759-9962 |
| Uncontrolled Keywords: | Polymer Science |
| Collections: | Nanomanufacturing Research Collection > Nanomanufacturing Nanoscale Science and Engineering Centers > Center for Hierarchical Manufacturing |
| Depositing User: | Robert Stevens |
| Date Deposited: | 12 Nov 2015 18:38 |
| Last Modified: | 12 Nov 2015 18:41 |
| URI: | http://eprints.internano.org/id/eprint/2349 |
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