Cruts, Bjoern and van Etten, Ludo and Tornqvist, Hakan and Blomberg, Anders and Sandstrom, Thomas and Mills, Nicholas L and Borm, Paul JA. (2008) Exposure to diesel exhaust induces changes in EEG in human volunteers. Particle and Fibre Toxicology, 5 (1). 4-online. ISSN 1743-8977
Full text not available from this repository. (Request a copy)Abstract
Background: Ambient particulate matter and nanoparticles have been shown to translocate to the brain, and potentially influence the central nervous system. No data are available whether this may lead to functional changes in the brain. Methods: We exposed 10 human volunteers to dilute diesel exhaust (DE, 300 μg/m3) as a model for ambient PM exposure and filtered air for one hour using a double blind randomized crossover design. Brain activity was monitored during and for one hour following each exposure using quantitative electroencephalography (QEEG) at 8 different sites on the scalp. The frequency spectrum of the EEG signals was used to calculate the median power frequency (MPF) and specific frequency bands of the QEEG. Results: Our data demonstrate a significant increase in MPF in response to DE in the frontal cortex within 30 min into exposure. The increase in MPF is primarily caused by an increase in fast wave activity (β2) and continues to rise during the 1 hour post-exposure interval. Conclusion: This study is the first to show a functional effect of DE exposure in the human brain, indicating a general cortical stress response. Further studies are required to determine whether this effect is mediated by the nanoparticles in DE and to define the precise pathways involved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | particulate matter, oxidative stress, air pollution, diesel, exhaust, inflammation, translocation, neurological disorder, cortex, human |
| InterNano Taxonomy: | Environment, Health, and Safety > Human Health > Toxicology Environment, Health, and Safety |
| Collections: | Nanomanufacturing Research Collection |
| Related URLs: | |
| Depositing User: | Mr. Richard L Rosen |
| Date Deposited: | 12 Jul 2010 19:41 |
| Last Modified: | 12 Jul 2010 19:41 |
| URI: | http://eprints.internano.org/id/eprint/491 |
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