nano-TAB: Specification to Facilitate Data Exchange Among Nanotechnology Resources

Harper, Stacey. (2010) nano-TAB: Specification to Facilitate Data Exchange Among Nanotechnology Resources. In: Nanoinformatics 2010, November 3 - 5, 2010, Arlington, VA. (Unpublished)

Preview

PDF Harper_nanoTAB.pdf - Presentation Download (875kB) | Preview

Abstract

The field of nanomedicine faces many challenges in the development of standards to support meaningful data submission and information exchange. Numerous physico-chemical, in vitro, and in vivo assays must be addressed, with measurements currently dependent on non-standardized protocols and diverse technology types. Representing Structure-Activity-Relationships (SARs) in nanomedicine, in particular, is critical to understanding the effects of nanomaterial structure on biological activity. Unfortunately, information describing the nanomaterial including functionalizing entities and 3D structure is often represented in an undisciplined fashion. This lack of standardization has been a significant deterrent to meaningful data sharing across the nanotechnology community; few publications contain sufficient information to enable adequate interpretation of results and successful achievement of experimental reproducibility. The nano-TAB effort aims to address data sharing challenges in nanotechnology by providing a standard means for identifying nanomaterials and characterizations in a tab-delimited format. nano-TAB is based on existing standards developed by the European Bioinformatics Institute (EBI) and the Investigation/Study/Assay (ISA-TAB) file format, which represents a variety of assays and technology types. The nano-TAB specification leverages ISA-TAB files describing investigations, study-samples, and assays and provides extensions to support nanomaterial structural information and assay measurements from the Washington University NanoParticle Ontology (NPO). The nano-TAB standard specification will enable the submission and exchange of nanomaterials to/from nanotechnology resources like the NCI’s caNanoLab nanotechnology portal and the Oregon State Nanomaterial-Biological Interactions (NBI) knowledgebase; empower organizations to adopt standards for representing data in nanotechnology publications; and provide researchers with guidelines for representing nanomaterials and characterizations to achieve cross-material comparison. The nano-TAB effort is a collaboration between a variety of organizations including the NCI, Washington University, Oregon State, ONAMI, NIOSH, Stanford University, and ISA-TAB. nano-TAB is registered as an ASTM Work Item, which facilitates a broad community outreach and input to the development of nano-TAB and other standards needed to support nanomedicine.

Actions (login required)

View Item